Adult 150-600 mg/day in 2 or 3 divided doses.
Neuropathic pain Initially, 150 mg/day in 2 or 3 divided doses. May be increased to 300 mg/day after 3-7 days. Max: 600 mg/day after an additional 7-day interval.
Epilepsy Initially, 150 mg/day in 2 or 3 divided doses. May be increased to 300 mg/day after 1 wk. Max: 600 mg/day after an additional wk.
GAD 150-600 mg/day given in 2-3 divided doses. Initially 150 mg/day, may be increased to 300 mg/day after 1 wk. Following an additional wk, dose may be increased to 450 mg/day. Max: 600 mg/day after an additional wk.
Fibromyalgia 300-450 mg daily. Initially 150 mg daily. May be increased to 300 mg daily w/in 1 wk. Max: 450 mg daily.
Renal impairment CrCl ≥60 mL/min Initially 150 mg/day to a max dose of 600 mg/day bid or tid,
≥30 to <60 mL/min Initially 75 mg/day to a max dose of 300 mg/day bid or tid,
≥15 to <30 mL/min Initially 25-50 mg/day to a max dose of 150 mg/day once daily or bid,
<15 mL/min 25 mg/day to a max dose of 75 mg/day once daily.
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